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EvidenceVariable "example-Wardlaw2014Analysis1.16.3EvidenceSet" Version "1"

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"Wardlaw 2014 Analysis 1.16.3 Evidence set" is a grouping of six Evidence results used in a meta-analysis.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-Wardlaw2014Analysis1.16.3EvidenceSet",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.921Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Wardlaw 2014 Analysis 1.16.3 Evidence set\" is a grouping of six Evidence results used in a meta-analysis.\n </p>\n&#x09;</div>"
  },
  "name" : "Wardlaw 2014 Analysis 1.16.3 Evidence set",
  "title" : "Wardlaw 2014 Analysis 1.16.3 Evidence set",
  "status" : "draft",
  "note" : [
    {
      "text" : "Short names for Evidence sources are detailed in \"References to studies included in this review\""
    }
  ],
  "relatedArtifact" : [
    {
      "type" : "citation",
      "label" : "Wardlaw 2014",
      "display" : "Analysis 1.16.3 from Wardlaw 2014",
      "citation" : "Wardlaw JM, Murray V, Berge E, del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev. 2014 Jul 29(7):CD000213. PMID 25072528",
      "url" : "https://doi.org/10.1002/14651858.CD000213.pub3"
    }
  ],
  "actual" : true,
  "characteristicCombination" : "union",
  "characteristic" : [
    {
      "definitionReference" : {
        "type" : "Evidence",
        "display" : "NINDS 1995"
      }
    },
    {
      "definitionReference" : {
        "type" : "Evidence",
        "display" : "ECASS 1995"
      }
    },
    {
      "definitionReference" : {
        "type" : "Evidence",
        "display" : "ECASS II 1998"
      }
    },
    {
      "definitionReference" : {
        "type" : "Evidence",
        "display" : "ATLANTIS B 1999"
      }
    },
    {
      "definitionReference" : {
        "type" : "Evidence",
        "display" : "ATLANTIS A 2000"
      }
    },
    {
      "definitionReference" : {
        "type" : "Evidence",
        "display" : "IST3 2012"
      }
    }
  ],
  "handling" : "dichotomous"
}

EvidenceVariable "example-Stroke-Thrombolysis-Trialists-2014-2016-IPD-MA-Cohort" Version "1"

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Stroke Thrombolysis Trialists’ Collaborators Group collection used for individual patient data meta-analysis


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-Stroke-Thrombolysis-Trialists-2014-2016-IPD-MA-Cohort",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.895Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n Stroke Thrombolysis Trialists&#x2019; Collaborators Group collection used for individual patient data meta-analysis\n </p>\n&#x09;</div>"
  },
  "name" : "Stroke Thrombolysis Trialists’ 2014-2016 IPD-MA Cohort",
  "title" : "Stroke Thrombolysis Trialists’ Collaborators Group collection used for individual patient data meta-analysis",
  "status" : "draft",
  "relatedArtifact" : [
    {
      "type" : "citation",
      "label" : "Emberson 2014",
      "display" : "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.",
      "citation" : "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063",
      "url" : "https://doi.org/10.1016/S0140-6736(14)60584-5"
    },
    {
      "type" : "citation",
      "label" : "Lees 2016",
      "display" : "Figure 2 Lees 2016",
      "citation" : "Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, et al; Stroke Thrombolysis Trialists’ Collaborators Group. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of 9 trials. Stroke. 2016;47:2373-2379. PMID 27507856",
      "url" : "https://doi.org/10.1161/STROKEAHA.116.013644"
    }
  ],
  "actual" : true,
  "characteristicCombination" : "union",
  "characteristic" : [
    {
      "definitionReference" : {
        "reference" : "Group/ECASSIII-Trial-Cohort",
        "type" : "Group",
        "display" : "ECASS III Trial Cohort"
      }
    },
    {
      "definitionReference" : {
        "reference" : "Group/IST3-Trial-Cohort",
        "type" : "Group",
        "display" : "IST3 Trial Cohort"
      }
    },
    {
      "definitionReference" : {
        "reference" : "Group/ECASS-Trial-Cohort",
        "type" : "Group",
        "display" : "ECASS Trial Cohort"
      }
    },
    {
      "definitionReference" : {
        "reference" : "Group/ECASSII-Trial-Cohort",
        "type" : "Group",
        "display" : "ECASSII Trial Cohort"
      }
    },
    {
      "definitionReference" : {
        "reference" : "Group/EPITHET-Trial-Cohort",
        "type" : "Group",
        "display" : "EPITHET Trial Cohort"
      }
    },
    {
      "definitionReference" : {
        "reference" : "Group/ATLANTIS-Trial-Cohort",
        "type" : "Group",
        "display" : "ATLANTIS Trial Cohort"
      }
    },
    {
      "definitionReference" : {
        "reference" : "Group/NINDS-Trial-Cohort",
        "type" : "Group",
        "display" : "NINDS Trial Cohort"
      }
    }
  ]
}

EvidenceVariable "example-placebo" Version "1"

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Placebo is a specific exposure that may be used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-placebo",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.843Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n&#x09;&#x09;<p>\n&#x09;&#x09;&#x09;Placebo is a specific exposure that may be used in expressing what an Evidence is about.\n&#x09;&#x09;</p>\n&#x09;</div>"
  },
  "title" : "placebo",
  "status" : "draft",
  "actual" : true,
  "characteristic" : [
    {
      "description" : "placebo",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "182886004",
            "display" : "Placebo given (situation)"
          }
        ]
      }
    }
  ]
}

EvidenceVariable "example-no-alteplase" Version "1"

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"No alteplase" is an intended exposure concept that may be used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-no-alteplase",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.796Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"No alteplase\" is an intended exposure concept that may be used in expressing what an Evidence is about.\n </p>\n&#x09;</div>"
  },
  "title" : "no alteplase",
  "status" : "draft",
  "actual" : false,
  "characteristic" : [
    {
      "description" : "no alteplase",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
            "code" : "8410",
            "display" : "alteplase"
          }
        ]
      },
      "exclude" : true
    }
  ]
}

EvidenceVariable "example-mRS3-6-at-90days" Version "1"

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"mRS 3-6 at 90 days" is an outcome, defined by a CQL expression, used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-mRS3-6-at-90days",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.750Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"mRS 3-6 at 90 days\" is an outcome, defined by a CQL expression, used in expressing what an Evidence is about.\n </p>\n&#x09;</div>"
  },
  "title" : "Modified Rankin Scale score 3-6 at 90 days after treatment",
  "status" : "draft",
  "actual" : true,
  "characteristic" : [
    {
      "description" : "mRS 3-6 at 90 days",
      "definitionExpression" : {
        "description" : "mRS 3-6",
        "language" : "text/cql",
        "expression" : "[\"Observation\": code in \"75859-9|LOINC\"] mRS where mRS.value between 3 and 6"
      },
      "timeFromStart" : {
        "quantity" : {
          "value" : 90,
          "unit" : "day",
          "system" : "http://unitsofmeasure.org",
          "code" : "d"
        }
      }
    }
  ],
  "handling" : "dichotomous"
}

EvidenceVariable "example-mRS0-2-at-90days" Version "1"

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This Resource , XML or JSON representation, or the full version history.. provenance for this resource
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"mRS 0-2 at 90 days" is an outcome, defined by a CQL expression, used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-mRS0-2-at-90days",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.718Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"mRS 0-2 at 90 days\" is an outcome, defined by a CQL expression, used in expressing what an Evidence is about.\n </p>\n&#x09;</div>"
  },
  "title" : "Modified Rankin Scale score 0-2 at 90 days after treatment",
  "status" : "draft",
  "actual" : true,
  "characteristic" : [
    {
      "description" : "mRS 0-2 at 90 days",
      "definitionExpression" : {
        "description" : "mRS 0-2",
        "language" : "text/cql",
        "expression" : "[\"Observation\": code in \"75859-9|LOINC\"] mRS where mRS.value between 0 and 2"
      },
      "timeFromStart" : {
        "quantity" : {
          "value" : 90,
          "unit" : "day",
          "system" : "http://unitsofmeasure.org",
          "code" : "d"
        }
      }
    }
  ],
  "handling" : "dichotomous"
}

EvidenceVariable "example-fatal-ICH-in-7-days" Version "1"

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"Fatal Intracranial Hemorrhage Within Seven Days" is an outcome used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-fatal-ICH-in-7-days",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.671Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Fatal Intracranial Hemorrhage Within Seven Days\" is an outcome used in expressing what an Evidence is about.\n </p>\n&#x09;</div>"
  },
  "title" : "Fatal Intracranial Hemorrhage Within Seven Days",
  "status" : "draft",
  "note" : [
    {
      "text" : "Death must be due to intracranial hemorrhage"
    }
  ],
  "actual" : true,
  "characteristicCombination" : "intersection",
  "characteristic" : [
    {
      "description" : "intracranial hemorrhage within 7 days",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "1386000",
            "display" : "Intracranial hemorrhage (disorder)"
          }
        ]
      },
      "timeFromStart" : {
        "description" : "within 7 days",
        "range" : {
          "low" : {
            "value" : 0,
            "unit" : "day",
            "system" : "http://unitsofmeasure.org",
            "code" : "d"
          },
          "high" : {
            "value" : 7,
            "unit" : "day",
            "system" : "http://unitsofmeasure.org",
            "code" : "d"
          }
        }
      }
    },
    {
      "description" : "death within 7 days",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "419620001",
            "display" : "Death (event)"
          }
        ]
      },
      "timeFromStart" : {
        "description" : "within 7 days",
        "range" : {
          "low" : {
            "value" : 0,
            "unit" : "day",
            "system" : "http://unitsofmeasure.org",
            "code" : "d"
          },
          "high" : {
            "value" : 7,
            "unit" : "day",
            "system" : "http://unitsofmeasure.org",
            "code" : "d"
          }
        }
      }
    }
  ],
  "handling" : "dichotomous"
}

EvidenceVariable "example-dead-or-dependent-90day" Version "1"

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"Dead or functionally dependent at 90 days" is an outcome used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-dead-or-dependent-90day",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.640Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Dead or functionally dependent at 90 days\" is an outcome used in expressing what an Evidence is about.\n </p>\n&#x09;</div>"
  },
  "title" : "Dead or functionally dependent at 90 days",
  "status" : "draft",
  "actual" : false,
  "characteristicCombination" : "union",
  "characteristic" : [
    {
      "description" : "functionally dependent at 90 days",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "718705001",
            "display" : "Functionally dependent (finding)"
          }
        ]
      },
      "timeFromStart" : {
        "quantity" : {
          "value" : 90,
          "unit" : "day",
          "system" : "http://unitsofmeasure.org",
          "code" : "d"
        }
      }
    },
    {
      "description" : "dead at 90 days",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "419099009",
            "display" : "Dead (finding)"
          }
        ]
      },
      "timeFromStart" : {
        "quantity" : {
          "value" : 90,
          "unit" : "day",
          "system" : "http://unitsofmeasure.org",
          "code" : "d"
        }
      }
    }
  ],
  "handling" : "dichotomous"
}

EvidenceVariable "example-alteplase-for-stroke" Version "1"

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"Alteplase for Stroke" is an exposure concept with a detailed dosing instruction that may be used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-alteplase-for-stroke",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.595Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Alteplase for Stroke\" is an exposure concept with a detailed dosing instruction that may be used in expressing what an Evidence is about.\n </p>\n&#x09;</div>"
  },
  "title" : "Alteplase for Stroke",
  "status" : "draft",
  "actual" : true,
  "characteristic" : [
    {
      "description" : "IV alteplase 0.9 mg/kg (maximum 90 mg) as 10% of dose over 1 minute and 90% over 1 hour",
      "definitionCanonical" : "http://example.org/fhir/ActivityDefinition/example-alteplase-dosing"
    }
  ]
}

EvidenceVariable "example-alive-independent-90day" Version "1"

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This Resource , XML or JSON representation, or the full version history.. provenance for this resource
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"Alive and not functionally dependent at 90 days" is an outcome used in expressing what an Evidence is about.


{
  "resourceType" : "EvidenceVariable",
  "id" : "example-alive-independent-90day",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2021-05-24T10:49:44.546Z",
    "tag" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code" : "HTEST",
        "display" : "test health data"
      }
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Alive and not functionally dependent at 90 days\" is an outcome used in expressing what an Evidence is about.\n </p>\n&#x09;</div>"
  },
  "title" : "Alive and not functionally dependent at 90 days",
  "status" : "draft",
  "actual" : false,
  "characteristicCombination" : "intersection",
  "characteristic" : [
    {
      "description" : "not functionally dependent at 90 days",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "718705001",
            "display" : "Functionally dependent (finding)"
          }
        ]
      },
      "exclude" : true,
      "timeFromStart" : {
        "quantity" : {
          "value" : 90,
          "unit" : "day",
          "system" : "http://unitsofmeasure.org",
          "code" : "d"
        }
      }
    },
    {
      "description" : "alive at 90 days",
      "definitionCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "419099009",
            "display" : "Dead (finding)"
          }
        ]
      },
      "exclude" : true,
      "timeFromStart" : {
        "quantity" : {
          "value" : 90,
          "unit" : "day",
          "system" : "http://unitsofmeasure.org",
          "code" : "d"
        }
      }
    }
  ],
  "handling" : "dichotomous"
}