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Evidence "example-stroke-no-alteplase-fatalICH" Version "1"

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This Resource , XML or JSON representation, or the full version history.. provenance for this resource
Updated: by

"Risk of fatal ICH without alteplase for stroke" is a univariate risk estimate.


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  },
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    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Risk of fatal ICH without alteplase for stroke\" is a univariate risk estimate.\n </p>\n&#x09;</div>"
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      "url" : "https://doi.org/10.1016/S0140-6736(14)60584-5"
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Evidence "example-stroke-alteplase-fatalICH" Version "1"

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This Resource , XML or JSON representation, or the full version history.. provenance for this resource
Updated: by

"Risk of fatal ICH with alteplase for stroke" is a univariate risk estimate.


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    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Risk of fatal ICH with alteplase for stroke\" is a univariate risk estimate.\n </p>\n&#x09;</div>"
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      "url" : "https://doi.org/10.1016/S0140-6736(14)60584-5"
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Evidence "example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2" Version "1"

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This Resource , XML or JSON representation, or the full version history.. provenance for this resource
Updated: by

"Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior" is a comparative effect estimate.


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    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior\" is a comparative effect estimate.\n </p>\n&#x09;</div>"
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  "url" : "Evidence/example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2",
  "title" : "Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior",
  "status" : "draft",
  "relatedArtifact" : [
    {
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      "display" : "Figure 2 Lees 2016",
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      "url" : "https://doi.org/10.1161/STROKEAHA.116.013644"
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  ],
  "description" : "mRS 0-2 at 90 days Odds Ratio 1.2 for Alteplase vs. No Alteplase in patients with acute ischemic stroke 3-4.5 hours prior",
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      },
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
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        },
        {
          "note" : [
            {
              "text" : "IST-3 had inconsistent results and contributed large proportion of data"
            }
          ],
          "type" : {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
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              }
            ]
          }
        },
        {
          "note" : [
            {
              "text" : "results derived from figure with limited data reported to support the specific effect estimate; derived odds ratio in figure does not match results from rates of mRS 0-2 reported in Supplementary Figure 3b"
            }
          ],
          "type" : {
            "coding" : [
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              }
            ]
          }
        },
        {
          "note" : [
            {
              "text" : "resuts derived for 3 - 4.5 hours assume data from 0 - 6 hours is informative"
            }
          ],
          "type" : {
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
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              }
            ]
          }
        },
        {
          "note" : [
            {
              "text" : "results largely influenced by IST-3 trial which was unblinded and ECASS III which had baseline imbalances"
            }
          ],
          "type" : {
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      ]
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  ]
}

Evidence "example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6" Version "1"

Tags: (no tags)  +

This Resource , XML or JSON representation, or the full version history.. provenance for this resource
Updated: by

"Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior" is a comparative effect estimate.


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  },
  "url" : "Evidence/example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6",
  "title" : "Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior",
  "status" : "draft",
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      "type" : "citation",
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      "citation" : "Wardlaw JM, Murray V, Berge E, del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev. 2014 Jul 29(7):CD000213. PMID 25072528",
      "url" : "https://doi.org/10.1002/14651858.CD000213.pub3"
    }
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        "display" : "mRS 3-6 at 90 days"
      },
      "intended" : {
        "reference" : "EvidenceVariable/example-dead-or-dependent-90day",
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    {
      "variableRole" : {
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        "system" : "http://terminology.hl7.org/CodeSystem/synthesis-type",
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        "display" : "summary data meta-analysis"
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      {
        "system" : "http://terminology.hl7.org/CodeSystem/study-type",
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            "system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
            "code" : "C16932",
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          }
        ]
      },
      "quantity" : {
        "value" : 0.65
      },
      "numberOfEvents" : 1137,
      "sampleSize" : {
        "numberOfStudies" : 6,
        "numberOfParticipants" : 1779
      },
      "attributeEstimate" : [
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          "description" : "95% CI 0.54 to 0.80",
          "type" : {
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                "code" : "C53324",
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            },
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        },
        {
          "description" : "P-value = 0.000023",
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          },
          "quantity" : {
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        },
        {
          "description" : "Heterogeneity I-sq = 0.0%",
          "type" : {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
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      ]
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      "description" : "Moderate certainty due to risk of bias",
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            "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
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            "code" : "moderate",
            "display" : "Moderate"
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        ]
      },
      "subcomponent" : [
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          "type" : {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
                "code" : "PublicationBias",
                "display" : "Publication bias"
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
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                "display" : "no serious concern"
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
                "code" : "Imprecision",
                "display" : "Imprecision"
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
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                "display" : "no serious concern"
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        },
        {
          "type" : {
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
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                "display" : "Indirectness"
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            ]
          },
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              }
            ]
          }
        },
        {
          "note" : [
            {
              "text" : "results largely influenced by IST-3 trial which was unblinded and NINDS trial which had allocation concealment not stated and baseline imbalances"
            }
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          "type" : {
            "coding" : [
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-type",
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                "system" : "http://terminology.hl7.org/CodeSystem/certainty-rating",
                "code" : "serious-concern",
                "display" : "serious concern"
              }
            ]
          }
        }
      ]
    }
  ]
}

Evidence "example-ASTRAL-12-alteplase-mRS3-6" Version "1"

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"Risk of mRS3-6 at 90 days after Alteplase for Stroke if ASTRAL score 12" is a univariate risk estimate.


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    "lastUpdated" : "2021-05-24T10:49:44.031Z"
  },
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    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <p>\n \"Risk of mRS3-6 at 90 days after Alteplase for Stroke if ASTRAL score 12\" is a univariate risk estimate.\n </p>\n&#x09;</div>"
  },
  "url" : "Evidence/example-ASTRAL-12-alteplase-mRS3-6",
  "title" : "Risk of mRS3-6 at 90 days after Alteplase for Stroke if ASTRAL score 12",
  "status" : "draft",
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      "type" : "citation",
      "label" : "Cooray 2016 Validation Study",
      "display" : "External Validation of the ASTRAL and DRAGON Scores for Prediction of Functional Outcome in Stroke.",
      "citation" : "Cooray C, Mazya M, Bottai M, Dorado L, Skoda O, Toni D, Ford GA, Wahlgren N, Ahmed N. External Validation of the ASTRAL and DRAGON Scores for Prediction of Functional Outcome in Stroke. Stroke. 2016 Jun;47(6):1493-9. Epub 2016 May 12. PMID 27174528",
      "url" : "https://doi.org/10.1161/STROKEAHA.116.012802"
    }
  ],
  "description" : "5.3% risk of mRS 3-6 at 90 days",
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      "sampleSize" : {
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          }
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}